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NFL Week 5 2022: Picks and predictions for every game

It’s time for the NFL Week 5 picks and predictions, and there are a litany of terrific games to break down for the weekend.

As always, all lines are provided by our partners at WynnBet.

Matchup

Indianapolis Colts

1-2-1

Denver Broncos

2-2

Thursday, Oct. 6

8:20 p.m. ET

Take both these teams — and their quarterbacks — to the glue factory. It’s going to be a battle of wills … for the teams and fans.

Pick: Denver 19, Indianapolis 17

Matchup

Green Bay Packers

3-1

New York Giants

3-1

Sunday, Oct. 9

9:30 p.m. ET

The Giants are surprising early, while the Packers are underwhelming. Yet both are 3-1, largely because Green Bay is so much more talented than most. Expect the Packers to prevail.

Pick: Green Bay 27, New York 20

Matchup

Atlanta Falcons

2-2

Tampa Bay Buccaneers

2-2

Tough to see the Buccaneers losing three straight games, let alone at home. Tom Brady will significantly outplay Marcus Mariota, and that’ll be the chief difference.

Pick: Tampa Bay 26, Atlanta 13

Matchup

Chicago Bears

2-2

Minnesota Vikings

3-1

The Vikings have a propensity to make games like this interesting, but the Bears don’t have enough firepower to win.

Pick: Minnesota 28, Chicago 15

Matchup

Detroit Lions

1-3

New England Patriots

1-3

Points will be scored. The question is who is under center for the Patriots, and can the Lions get a few key stops?

Pick: New England 30, Detroit 28

Matchup

Houston Texans

0-3-1

Jacksonville Jaguars

2-2

The Jaguars are showing real progress. The Texans are not. Jacksonville should handle business at home against Houston.

Pick: Jacksonville 29, Houston 17

Matchup

Los Angeles Chargers

2-2

Cleveland Browns

2-2

Toughest game to pick this week. Who the hell knows? Nick Chubb might run for 200 yards.

Pick: Cleveland 24, Los Angeles 23

Matchup

Miami Dolphins

3-1

New York Jets

2-2

How much of a difference is there between Teddy Bridgewater and Tua Tagovailoa? We’re about to  find out.

Pick: Miami 25, New York 23

Matchup

Pittsburgh Steelers

1-3

Buffalo Bills

3-1

This is going to be a ritualistic killing.

Pick: Buffalo 30, Pittsburgh 9

Matchup

Seattle Seahawks

2-2

New Orleans Saints

1-3

Why are the Saints favored by 5.5 points? They’ve been awful every game this season, while the Seahawks are 2-2 and playing really solid offense.

Pick: Seattle 24, New Orleans 22

Matchup

Tennessee Titans

2-2

Washington Commanders

1-3

Tennessee is back in business after winning the last two weeks, while Washington has lost three straight. Should be a close game, coming down to who makes a big mistake or two.

Pick: Tennessee 24, Washington 21

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